## Description

This 10th edition of Biostatistics: A Foundation for Analysis in the Health Sciences, 10th Edition should appeal to the same audience for which the first nine editions were written: advanced undergraduate students, beginning graduate students, and health professionals in need of a book on methodology. Like its predecessors, this edition requires few mathematical prerequisites.

Only reasonable proficiency in is required for an understanding of the concepts and underlying the calculations. The emphasis continues to be on an intuitive understanding of principles rather than an understanding based on mathematical sophistication. For most of the techniques covered in this edition, we discuss the capabilities of one or more software packages (MINITAB, SAS, SPSS, and NCSS) that may be used to perform the calculations needed for their application. Resulting screen displays are also shown.

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CHAPTER 1: INTRODUCTION TO BIOSTATISTICS
1.1 Introduction
1.2 Some Basic Concepts
1.3 Measurement and Measurement Scales
1.4 Sampling and Statistical Inference
1.5 The Scientific Method and the Design of Experiments
1.6 Computers and Biostatistical Analysis
1.7 Summary

CHAPTER 2: DESCRIPTIVE STATISTICS
2.1 Introduction
2.2 The Ordered Array
2.3 Grouped Data: The Frequency Distribution
2.4 Descriptive Statistics: Measures of Central Tendency
2.5 Descriptive Statistics: Measures of Dispersion
2.6 Summary

CHAPTER 3: SOME BASIC PROBABILITY CONCEPTS
3.1 Introduction
3.2 Two Views of Probability: Objective and Subjective
3.3 Elementary Properties of Probability
3.4 Calculating the Probability of an Event
3.5 Bayes' Theorem, Screening Tests, Sensitivity, Specificity, and Predictive Value Positive and Negative

CHAPTER 4: PROBABILITY DISTRIBUTIONS
4.1 Introduction
4.2 Probability Distribution of Discrete Variables
4.3 The Binomial Distribution
4.4 The Poisson Distribution
4.5 Continuous Probability Distributions
4.6 The Normal Distribution
4.7 Normal Distribution Applications
4.8 Summary

CHAPTER 5: SOME IMPORTANT SAMPLING DISTRIBUTIONS
5.1 Introduction
5.2 Sampling Distributions
5.3 Distribution of the Sample Mean
5.4 Distribution of the Difference Between Two Sample Means
5.5 Distribution of the Sample Proportion
5.6 Distribution of the Difference Between Two Summary
5.7 Summary

CHAPTER 6: ESTIMATION
6.1 Introduction
6.2 Confidence Interval for a Population Mean
6.3 The t Distribution
6.4 Confidence Interval for the Difference Between Two Population Means
6.5 Confidence Interval for a Population Proportion
6.6 Confidence Interval for the Difference Between Two Population Proportions
6.7 Determination of Sample Size for Estimating Means
6.8 Determination of Sample Size for Estimating Proportions
6.9 Confidence Interval for the Variance of a Normally Distributed Population
6.10 Confidence Interval for the Ratio of the Variances of Two Normally Distributed Populations
6.11 Summary

CHAPTER 7: HYPOTHESIS TESTING
7.1 Introduction
7.2 Hypothesis Testing: A Single Population Mean
7.3 Hypothesis Testing: The Difference Between Two Population Means
7.4 Paired Comparisons
7.5 Hypothesis Testing: A Single Population Proportion
7.6 Hypothesis Testing: The Difference Between Two Population Proportions
7.7 Hypothesis Testing: A Single Population Variance
7.8 Hypothesis Testing: The Ratio of Two Population Variances
7.9 The Type II Error and the Power of a Test
7.10 Determining Sample Size to Control Type II Errors
7.11 Summary

CHAPTER 8: ANALYSIS OF VARIANCE
8.1 Introduction
8.2 The Completely Randomized Design
8.3 The Randomized Complete Block Design
8.4 The Repeated Measures Design
8.5 The Factorial Experiment
8.6 Summary

CHAPTER 9: SIMPLE LINEAR REGRESSION AND CORRELATION
9.1 Introduction
9.2 The Regression Model
9.3 The Sample Regression Equation
9.4 Evaluating the Regression Equation
9.5 Using the Regression Equation
9.6 The Correlation Model
9.7 The Correlation Coefficient
9.8 Some Precautions
9.9 Summary

CHAPTER 10: MULTIPLE REGRESSION AND CORRELATION
10.1 Introduction
10.2 The Multiple Linear Regression Model
10.3 Obtaining the Multiple Regression Equation
10.4 Evaluating the Multiple Regression Equation
10.5 Using the Multiple Regression Equation
10.6 The Multiple Correlation Model
10.7 Summary

CHAPTER 11: REGRESSION ANALYSIS: SOME ADDITIONAL TECHNIQUES
11.1 Introduction
11.2 Qualitative Independent Variables
11.3 Variable Selection Procedures
11.4 Logistic Regression
11.5 Summary

CHAPTER 12: THE CHI-SQUARE DISTRIBUTION AND THE ANALYSIS OF FREQUENCIES
12.1 Introduction
12.2 The Mathematical Properties of the Chi-Square Distribution
12.3 Tests of Goodness-of-Fit
12.4 Tests of Independence
12.5 Tests of Homogeneity
12.6 The Fisher Exact Test
12.7 Relative Risk, Odds Ratio, and the Mantel-Haenszel Statistics
12.8 Summary

CHAPTER 13: NONPARAMETRIC AND DISTRIBUTION-FREE STATISTICS
13.1 Introduction
13.2 Measurement Scales
13.3 The Sign Test
13.4 The Wilcoxon Signed-Rank Test for Location
13.5 The Median Test
13.6 The Mann-Whitney Test
13.7 The Kolmogorov-Smirnov Goodness-of-Fit Test
13.8 The Kruskal-Wallis One-Way Analysis of Variance by Ranks
13.9 The Friedman Two-Way Analysis of Variance by Ranks
13.10 The Spearman Rank Correlation Coefficient
13.11 Nonparametric Regression Analysis
13.12 Summary

CHAPTER 14: SURVIVAL ANALYSIS
14.1 Introduction
14.2 Time-to-Event Data and Censoring
14.3 The Kaplan-Meier Procedure
14.4 Comparing Survival Curves
14.5 Cox Regression: The Proportional Hazards Model
14.6 Summary

CHAPTER 15: VITAL STATISTICS (ONLINE)
15.1 Introduction
15.2 Death Rates and Ratios
15.3 Measures of Fertility
15.4 Measure of Morbidity
15.5 Summary

APPENDIX: STATISTICAL TABLES 