Introduction to Biomedical Engineering – John Enderle, Susan M. Blanchard, Joseph Bronzino – 2nd Edition

Description

Under the direction of John Enderle, Susan and Joe Bronzino, leaders in the field have contributed chapters on the most relevant subjects for students. These chapters coincide with courses offered in all biomedical programs so that it can be used at different levels for a variety of courses of this evolving field.

Introduction to Biomedical Engineering, Second Edition provides a historical perspective of the major developments in the biomedical field. Also contained within are the fundamental principles underlying design, analysis, and modeling procedures. The numerous examples, drill and exercises are used to reinforce concepts and develop problem-solving skills making this book an invaluable tool for all biomedical students and engineers.

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  • Dedication
    PREFACE
    ACKNOWLEDGEMENTS
    CONTRIBUTORS TO THE FIRST EDITION
    CONTRIBUTORS TO THE SECOND EDITION
    1. BIOMEDICAL ENGINEERING: A HISTORICAL PERSPECTIVE
    1.1 EVOLUTION OF THE MODERN HEALTH CARE SYSTEM
    1.2 THE MODERN HEALTH CARE SYSTEM
    1.3 WHAT IS BIOMEDICAL ENGINEERING
    1.4 ROLES PLAYED BY BIOMEDICAL ENGINEERS
    1.5 PROFESSIONAL STATUS OF BIOMEDICAL ENGINEERING
    1.6 PROFESSIONAL SOCIETIES
    EXERCISES
    REFERENCES AND SUGGESTED READING
    2. MORAL AND ETHICAL ISSUES
    2.1 MORALITY AND ETHICS: A DEFINITION OF TERMS
    2.2 TWO MORAL NORMS: BENEFICENCE AND NONMALEFICENCE
    2.3 REDEFINING DEATH
    2.4 THE TERMINALLY ILL PATIENT AND EUTHANASIA
    2.5 TAKING CONTROL
    2.6 HUMAN EXPERIMENTATION
    2.7 DEFINITION AND PURPOSE OF EXPERIMENTATION
    2.8 INFORMED CONSENT
    2.9 REGULATION OF MEDICAL DEVICE INNOVATION
    2.10 MARKETING MEDICAL DEVICES
    2.11 ETHICAL ISSUES IN FEASIBILITY STUDIES
    2.12 ETHICAL ISSUES IN EMERGENCY USE
    2.13 ETHICAL ISSUES IN TREATMENT USE
    2.14 THE ROLE OF THE BIOMEDICAL ENGINEER IN THE FDA PROCESS
    EXERCISES
    SUGGESTED READING
    3. ANATOMY AND PHYSIOLOGY
    3.1 INTRODUCTION
    3.2 CELLULAR ORGANIZATION
    3.3 Tissues
    3.4 MAJOR ORGAN SYSTEMS
    3.5 HOMEOSTASIS
    EXERCISES
    SUGGESTED READING
    4. BIOMECHANICS
    4.1 INTRODUCTION
    4.2 BASIC MECHANICS
    4.3 MECHANICS OF MATERIALS
    4.4 VISCOELASTIC PROPERTIES
    4.5 CARTILAGE, LIGAMENT, TENDON, AND MUSCLE
    4.6 CLINICAL GAIT ANALYSIS
    4.7 CARDIOVASCULAR DYNAMICS
    Exercises
    SUGGESTED READING
    5. REHABILITATION ENGINEERING AND ASSISTIVE TECHNOLOGY
    5.1 INTRODUCTION
    5.2 THE HUMAN COMPONENT
    5.3 PRINCIPLES OF ASSISTIVE TECHNOLOGY ASSESSMENT
    5.4 PRINCIPLES OF REHABILITATION ENGINEERING
    5.5 PRACTICE OF REHABILITATION ENGINEERING AND ASSISTIVE TECHNOLOGY
    EXERCISES
    SUGGESTED READING
    6. BIOMATERIALS
    6.1 MATERIALS IN MEDICINE: FROM PROSTHETICS TO REGENERATION
    6.2 BIOMATERIALS: PROPERTIES, TYPES, AND APPLICATIONS
    6.3 LESSONS FROM NATURE ON BIOMATERIAL DESIGN AND SELECTION
    6.4 TISSUE–BIOMATERIAL INTERACTIONS
    6.5 GUIDING TISSUE REPAIR WITH BIO-INSPIRED BIOMATERIALS
    6.6 SAFETY TESTING AND REGULATION OF BIOMATERIALS
    6.7 APPLICATION-SPECIFIC STRATEGIES FOR THE DESIGN AND SELECTION OF BIOMATERIALS
    EXERCISES
    SUGGESTED READING
    7. TISSUE ENGINEERING
    7.1 WHAT IS TISSUE ENGINEERING?
    7.2 BIOLOGICAL CONSIDERATIONS
    7.3 PHYSICAL CONSIDERATIONS
    7.4 SCALING UP
    7.5 IMPLEMENTATION OF TISSUE ENGINEERED PRODUCTS
    7.6 FUTURE DIRECTIONS: FUNCTIONAL TISSUE ENGINEERING AND THE “-OMICS” SCIENCES
    7.7 CONCLUSIONS
    7.8 Glossary
    EXERCISES
    SUGGESTED READING
    8. BIOINSTRUMENTATION
    8.1 INTRODUCTION
    8.2 BASIC BIOINSTRUMENTATION SYSTEM
    8.3 CHARGE, CURRENT, VOLTAGE, POWER, AND ENERGY
    8.4 RESISTANCE
    8.5 LINEAR NETWORK ANALYSIS
    8.6 LINEARITY AND SUPERPOSITION
    8.7 THÉVENIN’S THEOREM
    8.8 INDUCTORS
    8.9 CAPACITORS
    8.10 A GENERAL APPROACH TO SOLVING CIRCUITS INVOLVING RESISTORS, CAPACITORS, AND INDUCTORS
    8.11 OPERATIONAL AMPLIFIERS
    8.12 TIME-VARYING SIGNALS
    8.13 ACTIVE ANALOG FILTERS
    8.14 BIOINSTRUMENTATION DESIGN
    Exercises
    SUGGESTED READING
    9. BIOMEDICAL SENSORS
    9.1 INTRODUCTION
    9.2 BIOPOTENTIAL MEASUREMENTS
    9.3 PHYSICAL MEASUREMENTS
    9.4 BLOOD GASES AND PH SENSORS
    9.5 BIOANALYTICAL SENSORS
    9.6 OPTICAL BIOSENSORS
    EXERCISES
    SUGGESTED READING
    10. BIOSIGNAL PROCESSING
    10.1 INTRODUCTION
    10.2 PHYSIOLOGICAL ORIGINS OF BIOSIGNALS
    10.3 CHARACTERISTICS OF BIOSIGNALS
    10.4 SIGNAL ACQUISITION
    10.5 FREQUENCY DOMAIN REPRESENTATION OF BIOLOGICAL SIGNALS
    10.5.5 Properties of the Fourier Transform
    10.6 LINEAR SYSTEMS
    10.7 SIGNAL AVERAGING
    10.8 WAVELET TRANSFORM AND SHORT-TIME FOURIER TRANSFORM
    10.9 ARTIFICIAL INTELLIGENCE TECHNIQUES
    EXERCISES
    SUGGESTED READING
    11. BIOELECTRIC PHENOMENA
    11.1 INTRODUCTION
    11.2 HISTORY
    11.3 NEURONS
    11.4 BASIC BIOPHYSICS TOOLS AND RELATIONSHIPS
    11.5 EQUIVALENT CIRCUIT MODEL FOR THE CELL MEMBRANE
    11.6 HODGKIN–HUXLEY MODEL OF THE ACTION POTENTIAL
    11.7 MODEL OF THE WHOLE NEURON
    EXERCISES
    SUGGESTED READING
    12. PHYSIOLOGICAL MODELING
    12.1 INTRODUCTION
    12.2 COMPARTMENTAL MODELING
    12.3 AN OVERVIEW OF THE FAST EYE MOVEMENT SYSTEM
    12.4 WESTHEIMER SACCADIC EYE MOVEMENT MODEL
    12.5 THE SACCADE CONTROLLER
    12.6 DEVELOPMENT OF AN OCULOMOTOR MUSCLE MODEL
    12.7 A LINEAR MUSCLE MODEL
    12.8 A LINEAR HOMEOMORPHIC SACCADIC EYE MOVEMENT MODEL
    12.9 A TRUER LINEAR HOMEOMORPHIC SACCADIC EYE MOVEMENT MODEL
    12.10 SYSTEM IDENTIFICATION
    EXERCISES
    SUGGESTED READING
    13. GENOMICS AND BIOINFORMATICS
    13.1 INTRODUCTION
    13.2 CORE LABORATORY TECHNOLOGIES
    13.3 CORE BIOINFORMATICS TECHNOLOGIES
    13.4 CONCLUSION
    EXERCISES
    SUGGESTED READING
    14. COMPUTATIONAL CELL BIOLOGY AND COMPLEXITY
    14.1 COMPUTATIONAL BIOLOGY
    14.2 THE MODELING PROCESS
    14.3 BIONETWORKS
    14.4 INTRODUCTION TO COMPLEXITY THEORY
    EXERCISES
    SUGGESTED READING
    15. RADIATION IMAGING
    15.1 INTRODUCTION
    15.2 EMISSION IMAGING SYSTEMS
    15.3 INSTRUMENTATION AND IMAGING DEVICES
    15.4 RADIOGRAPHIC IMAGING SYSTEMS
    EXERCISES
    SUGGESTED READING
    16. MEDICAL IMAGING
    16.1 INTRODUCTION
    16.2 DIAGNOSTIC ULTRASOUND IMAGING
    16.3 MAGNETIC RESONANCE IMAGING (MRI)
    16.4 COMPARISON OF IMAGING MODES
    EXERCISES
    SUGGESTED READING
    17. BIOMEDICAL OPTICS AND LASERS
    17.1 INTRODUCTION TO ESSENTIAL OPTICAL PRINCIPLES
    17.2 FUNDAMENTALS OF LIGHT PROPAGATION IN BIOLOGICAL TISSUE
    17.3 Physical Interaction of Light and Physical Sensing
    17.4 BIOCHEMICAL MEASUREMENT TECHNIQUES USING LIGHT
    17.5 Fundamentals of Photothermal Therapeutic Effects of Lasers
    17.6 FIBER OPTICS AND WAVEGUIDES IN MEDICINE
    17.7 BIOMEDICAL OPTICAL IMAGING
    EXERCISES
    SUGGESTED READING
    APPENDIX
    A.1 MATLAB
    A.2 Solving Differential Equations Using MATLAB
    A.3 BLOCK DIAGRAMS AND SIMULINK
    A.4 SIMULINK
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